Phytosome Loading the Combined Extract of Mulberry Fruit and Ginger Protects against Cerebral Ischemia in Metabolic Syndrome Rats

Table 2

The effect of various doses of PMG on oxidative stress markers in the cerebral cortex.

Treatment groups	MDA (ng/mg protein)	SOD (units/mg protein)	CAT (units/mg protein)	GSH-Px (units/mg protein)
ND+vehicle
HCHF+sham+vehicle
HCHF+MCAO+vehicle	^aaa, bbb	^aaa, bbb	^aaa, bbb	^aaa, bbb
HCHF+MCAO+vitamin C
HCHF+MCAO+Piracetam
HCHF+MCAO+PMG 50
HCHF+MCAO+PMG 100
HCHF+MCAO+PMG 200

Data are presented as (/group). ^aaa values < 0.001; compared between naïve control rats which received normal diet and vehicle, and metabolic syndrome+MCAO rats which received HCHF, MCAO, and vehicle, ^bbb values < 0.001; compared between sham rats which received HCHF, sham operation, and vehicle, and metabolic syndrome+MCAO rats which received HCHF, MCAO, and vehicle and , , values < 0.05, 0.01, and 0.001, respectively; compared to metabolic syndrome+MCAO rats which received HCHF, MCAO, and vehicle. ND: normal diet; HCHF: high-carbohydrate high-fat diet; MCAO: middle cerebral artery occlusion; vitamin C: the Vitamin C at a dose of 250 mg.kg^-1 BW; piracetam: the piracetam at a dose of 250 mg.kg^-1 BW; PMG 50, PMG 100, and PMG 200: the phytosome containing the combined extract of mulberry fruit and ginger at doses of 50, 100, and 200 mg.kg^-1 BW, respectively.