Cellular Mechanisms Triggered by the Cotreatment of Resveratrol and Doxorubicin in Breast Cancer: A Translational In Vitro–In Silico Model

Figure 6

Fourteen H-B genes are directly modulated by Rsv, Doxo, or the combination, and nine out of these genes affect the survival of breast cancer patients. (a) Networks show only nodes directly modulated by Rsv or Doxo in MCF7 and breast cancer. Overlapping gene expression data with each network was performed. Red and blue nodes represent genes that are up- or downregulated, respectively, in cancer in comparison to normal mammary tissue. (b) Kaplan-Meier survival curves of nine H-B genes in breast cancer patients.

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