Research Article

The Role of DNMT and HDACs in the Fetal Programming of Hypertension by Glucocorticoids

Figure 1

Schematic of fetal programming and epigenetic inhibitor administration. Pregnant WKY dams received 100 μg/kg/day dexamethasone S.C. from gestational days 15-21. Pups exposed to Dex in utero are shown in black. Weekly BP measurements were taken from weeks 4 to 14. Injections with the DNMT inhibitor 5aza2DC or VPA began at week 12 until sacrifice at the end of week 14. Adrenal glands were collected for protein and gene expression analysis, and plasma was collected for catecholamine analysis.