EGCG Attenuates Renal Damage via Reversing Klotho Hypermethylation in Diabetic db/db Mice and HK-2 Cells

Figure 1

Detection of the protein expression of Klotho, DNMT1, DNMT3a, and DNMT3b in the kidney tissues of mice by western blotting. (a and b) The protein expression of Klotho. (c–e) The protein expression of Klotho, DNMT1, DNMT3a, and DNMT3b. Normal group: nontreated C57 mice. Control group: nontreated db/db mice. EGCG group: db/db mice treated with EGCG (50 mg/kg/d). Values are expressed as . vs. nontreated db/db mice. ^## vs. nontreated C57 mice.

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