Role of Nrf2 in Lipopolysaccharide-Induced Acute Kidney Injury: Protection by Human Umbilical Cord Blood Mononuclear Cells

Figure 5

The changes of mitochondrial damage and autophagy-associated proteins in intervention experiment. Western blot was used to detect the expression of mfn2, Drp1, p62, PINK1, Parkin, and LC3. Mitochondria injury in rat kidney tissues was observed by transmission electron microscopy (TEM). (a) Representative blots of mfn2, Drp1, p62, PINK1, Parkin, LC3, and β-actin. (b) Densitometry of mfn2. (c) Densitometry of Drp1. (d) Densitometry of p62. (e) Densitometry of PINK1. (f) Densitometry of Parkin. (g) Densitometry of LC3-II. (h) Representative photomicrographs of mitochondria injury in rat kidney tissues (original magnifications: ×10000, under a Hitachi H7700 electron microscope). Values are , for each group. ^★ versus the control group. ^# versus the LPS group. ^∆ versus the LPS+MNCs group.

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