Berberine Attenuates Hyperglycemia by Inhibiting the Hepatic Glucagon Pathway in Diabetic Mice

Figure 1

BBR improves glucose metabolism in diabetic mice. (a–d) ob/ob mice were treated with saline (control) or BBR intraperitoneally once a day for 3 weeks while consuming a normal chow diet. (a) Feeding and fasting blood glucose. , compared with the control group (). (b) Fasting plasma insulin levels in ob/ob mice for 18 weeks. , compared with the control group (). GTTs (c) and ITTs (d) were performed in ob/ob mice for 19 and 20 weeks, and areas under the curve (AUCs) were calculated. , compared with the control group (). (e, f) The age-matched mice were treated with saline (normal), and the STZ-induced mice were treated with saline (STZ) or BBR (STZ+BBR) once a day for 3 weeks while consuming a normal chow diet. (e) Fasting blood glucose and 12 hr AUCs of the STZ and BBR groups. , compared with the STZ group (). (f) Glucose tolerance tests were performed, and areas under the curve (AUCs) were calculated. Each value represents the , compared with the STZ group ().

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