Simvastatin Attenuates Abdominal Aortic Aneurysm Formation Favoured by Lack of Nrf2 Transcriptional Activity

Figure 1

Simvastatin reduces the risk of AAA formation and rupture in Nrf2 tKO mice. Mice of both genotypes were divided into the following groups: (1) sham (saline, ), (2) angiotensin II (AngII group, or 14), (3) simvastatin+saline (Sim group, ), and (4) simvastatin+angiotensin II (Sim+AngII group, ). Simvastatin was administered daily for 7 consecutive days before osmotic pump placement and during AngII infusion for another 28 days. (a) The frequency of aortic aneurysm appearance (Fisher’s exact test), and (b) representative image of aortas isolated from WT and Nrf2 tKO mice. Hashtag indicates a dissected aneurysm. . (c) The frequency of aneurysm rupture (Fisher’s exact test). (d) Time-dependent changes in the aortic inner diameter measured with USG. Three-way ANOVA and Tukey’s post hoc test. (e) Representative images of aortic inner diameter changes in WT and Nrf2 tKO mice at days 7 and 28 of AngII and Sim+AngII treatment and vs. saline; ^# and ^## vs. AngII.

(a)

(b)

(c)

(d)

(e)