Simvastatin Attenuates Abdominal Aortic Aneurysm Formation Favoured by Lack of Nrf2 Transcriptional Activity
Simvastatin mitigates AngII-induced changes in collagen and elastin status. Mice of both genotypes represent the following groups: (1) sham (saline, ), (2) angiotensin II (AngII group, ), (3) simvastatin+saline (Sim group, ), and (4) simvastatin+angiotensin II (Sim+AngII group, ). Simvastatin was administered daily for 7 consecutive days before osmotic pump placement and during AngII infusion for another consecutive 14 days. (a) Verhoeff’s Van Gieson staining of abdominal aortas for elastin fibers at magnification 200x. L: lumen. ; arrow—elastin breaks. (b) Relative expression of Col1α1, Col1α2, and Col3α1 within the abdominal aortic wall. eEF2 was used as a reference gene. Three-way ANOVA with Tukey’s post hoc test. Rectangle—mice, which developed the aneurysm. Immunofluorescent staining of (c) collagen I and (d) collagen III within the abdominal aorta at magnification 200x. L: lumen. Collagen: red; nuclei: blue. Representative images. . and vs. saline; # and ### vs. AngII.
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