Ceftriaxone Calcium Crystals Induce Acute Kidney Injury by NLRP3-Mediated Inflammation and Oxidative Stress Injury
Rats administered with high concentration of ceftriaxone and calcium developed AKI. (a) Concentrations of blood urea nitrogen (mg/dL). (b) Concentrations of creatinine (mg/dL) ( for each group; the results are expressed as ; compared with the control group). (c, d) Representative H&E-stained kidney sections ((c) NC group; (d) group 1, μm). Injury scores were 1 and 4, respectively. The arrows indicated the representative morphological changes including severe interstitial edema, cellular infiltrate, tubular cell swelling, and necrosis.
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