Danshen Attenuates Intervertebral Disc Degeneration via Antioxidation in SD Rats

<div>Imaging characteristics of IVDs in each group after 2 and 4 weeks. (a) Representative radiographs (X-ray) of the Co8-9 discs in the control group, IDD group, and Danshen IDD group. (b) Analysis of disc height index (DHI) based on X-ray film. A significant decrease of %DHI was observed in the IDD group. However, this reduction of disc space was significantly alleviated in the Danshen IDD group. (c) Representative images of T2-weighted MRI in Co8-9 discs. (d) Analysis of signal intensity based on MRI. Punctured discs in the IDD group showed a significant decrease of MRI signal intensity. However, the signal intensity in the Danshen IDD group was significantly higher compared to that in the IDD group. 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-12Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.204,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,44.444,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg>.</span> IDD: intervertebral disc degeneration.</div>

Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Danshen Attenuates Intervertebral Disc Degeneration via Antioxidation in SD Rats 