| Substrate | Lysine site | Function | Reference |
| p53 | K382 | Apoptosis and senescence | [42, 43] | NF-κB p65 | K310 | Apoptosis and inflammation | [45] | Ku70 | K539, K542, K544, K533, and K556 | DNA repair | [48] | FOXO1 | K222, K245, K248, K262, K265, K274, and K294 | Apoptosis | [50] | FOXO3 | K242, K259, K271, K290, and K569 | Cell cycle arrest, oxidative stress | [50] | FOXO4 | K186, K189, and K408 | Oxidative stress | [50] | HIF-1α | K674 | Cell invasion | [53] | HIF-2α | K385, K685, and K741 | Cell survival | [53] | PGC-1α | K13 | Mitochondrial biogenesis and metabolism | [58] | STAT3 | K685, K679, K707, and K709 | Gluconeogenesis and cell proliferation | [60] |
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