The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases

Table 1

The substrates of SIRT1.

Substrate	Lysine site	Function	Reference
p53	K382	Apoptosis and senescence	[42, 43]
NF-κB p65	K310	Apoptosis and inflammation	[45]
Ku70	K539, K542, K544, K533, and K556	DNA repair	[48]
FOXO1	K222, K245, K248, K262, K265, K274, and K294	Apoptosis	[50]
FOXO3	K242, K259, K271, K290, and K569	Cell cycle arrest, oxidative stress	[50]
FOXO4	K186, K189, and K408	Oxidative stress	[50]
HIF-1α	K674	Cell invasion	[53]
HIF-2α	K385, K685, and K741	Cell survival	[53]
PGC-1α	K13	Mitochondrial biogenesis and metabolism	[58]
STAT3	K685, K679, K707, and K709	Gluconeogenesis and cell proliferation	[60]