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| Chemical agents | Models | Involved mechanisms | Effect | Reference |
|
| Resveratrol | BV2 microglia cell lines induced by amyloid-beta (Aβ) | Upregulation of SIRT1 inhibits TXNIP/TRX/NLRP3 and NF-κB signaling pathway | Suppression of inflammatory cytokines (IL-1β, IL-6, and TNF-α) | Feng and Zhang [117] |
| Resveratrol | BV2 microglia cell lines induced by ATP and LPS | Upregulation of SIRT1 inhibits NLRP3 inflammasome signaling pathway | Suppression of inflammatory cytokine IL-1β | Sui et al. [118] |
| Resveratrol | Sepsis-associated encephalopathy mouse model induced by cecal ligation and puncture (CLP) | Upregulation of SIRT1 inhibits NLRP3 inflammasome signaling pathway | Suppression of inflammatory cytokine IL-1β, activation of microglia in the hippocampus | Sui et al. [118] |
| Resveratrol | Estrogen deficiency-induced depression-like behavior mouse model | Upregulation of SIRT1 inhibits NLRP3 inflammasome and NF-κB signaling pathway | Suppression of inflammatory cytokines (IL-1β and IL-18) and activation of microglia in the hippocampus | Liu et al. [119] |
| Resveratrol | Subarachnoid hemorrhage rat model | Upregulation of SIRT1 inhibits NLRP3 inflammasome signaling pathway | Suppression of inflammatory cytokines (IL-1β, IL-18, and TNF-α), microglia activation, and neutrophil infiltration | Zhang et al. [120] |
| Resveratrol | Isoflurane-induced cognitive impairment mouse model | Upregulation of SIRT1 inhibits the expression of NLRP3 inflammasome | Suppression of inflammatory cytokines ( IL-1β and TNF-α) in the hippocampus | Li et al. [121] |
| Resveratrol | Traumatic brain injury rat model | Upregulation of SIRT1 inhibits NLRP3 inflammasome signaling pathway | Suppression of inflammatory cytokines ( IL-1β and IL-18) and ROS | Zou et al. [122] |
| Resveratrol | Middle cerebral artery occlusion (MCAO) rat model | Resveratrol inhibits NLRP3 inflammasome signaling pathway by upregulated autophagy | Suppression of inflammatory cytokines (IL-1β and IL-18) | He et al. [123] |
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