The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases

Table 4

SIRT1 regulate neuroinflammation involved in the MAPK pathway.

Chemical agents	Models	Involved mechanisms	Effect	Reference
Resveratrol or adenoviral vectors	IL-1β-stimulated primary cortical astrocyte model	Overexpression of SIRT1 or resveratrol inhibits the MAPK pathway	Suppression of the astrocyte activation	Li et al. [126]
Resveratrol	Hypoxia-induced cytotoxicity in BV2 microglial cells	Resveratrol inhibits ERK and JNK MAPK signaling pathways and the NF-κB pathway	Suppression of inflammatory cytokines (IL-1β and TNF-α)	Zhang et al. [127]
Resveratrol-enriched rice (RR)	LPS-activated BV2 microglial cells	RR inhibits MAPK signaling pathways and NF-κB translocation	Suppression of inflammatory cytokines (iNOS, COX-2, TNF-α, IL-1β, and IL-6)	Subedi et al. [128]
Resveratrol	Alcohol-induced neurodegeneration rat and SH-SY5Y cells	Resveratrol inhibits the activation of the p38 MAPK pathway	Suppression of inflammatory cytokine TNF-α and reduction of alcohol-induced neuron damage in the hippocampus	Gu et al. [129]
Sirtinol	Traumatic brain injury (TBI) rat model	Sirtinol exacerbate the activation of the p38 MAPK pathway	Promotion of TBI-induced mitochondrial damage and neuronal apoptosis in injured-side cortexes	Yang et al. [130]
Salermide and SIRT1 siRNA	Primary cortical neurons induced by scratch injury	Salermide and SIRT1 siRNA inhibit the activation of the ERK1/2 pathway	Promotion of apoptotic neuron death	Zhao et al. [131]
Salermide	Traumatic brain injury (TBI) mice model	Salermide inhibits the activation of the ERK1/2 pathway	Promotion of apoptotic neuron death in injured-side cortex	Zhao et al. [131]