Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling

Figure 3

PASMC proliferation in response to prohypertensive growth factor was inhibited by dichloroacetate and atorvastatin exposure. (a, b) Cell viability assay in PASMCs exposed to (a) dichloroacetate () and (b) atorvastatin (). , , and indicate , , and , respectively, comparing the control group. (c) Cell viability assay in PASMCs treated with different concentrations of atorvastatin with or without 5 mM dichloroacetate (). and indicate and , respectively, comparing the non-DCA group. (f) White field of PASMCs showed characteristic morphological changes. Scale bar: 100 μm.

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