The MUC5B Mucin Is Involved in Paraquat-Induced Lung Inflammation

Figure 3

MAPK/NF-κB signaling pathway activation by PQ exposure. (a) Cells were treated with 50 μM PQ for a time-dependent experiment (0, 5, 15, 30, 45, and 60 min). Phosphorylation levels of ERK, JNK, p38, and p65 were detected by Western blot analysis. Quantitative data are provided. The phosphorylated forms of (b) ERK, (c) JNK, (d) p38, and (e) p65 all start increased from 5 min after PQ treatment and significantly at 30 min (p-p65/p65, p-JNK/JNK, p-p38/p38) or 15 min (p-ERK/ERK). The results are expressed as the of three different experiments. , , , compared with the time 0 h.

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