A Novel Molecular Mechanism of IKKε-Mediated Akt/mTOR Inhibition in the Cardiomyocyte Autophagy after Myocardial Infarction
IKKε levels were increased in cardiomyocytes of the mouse postinfarction hearts. (a) Representative images of H&E staining, Masson staining, and immunohistochemical staining of IKKε transverse sections from a sham heart and an infarcted heart at 14 days after MI ( for each group; magnification, 200x). Scale bar represents 100 μm. (b, c) IKKε expression levels of the mouse hearts were detected via western blotting analysis ( per experimental group). . (d) Immunofluorescence staining images labeling IKKε (green) and troponin (red) in the border zones of MI mice at 14 days ( for each group; magnification, 200x). Scale bars represent 100 μm. Each experiment was repeated 3 times.
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