Oxidative Medicine and Cellular Longevity / 2020 / Article / Fig 4

Research Article

MG53 Protects against Sepsis-Induced Myocardial Dysfunction by Upregulating Peroxisome Proliferator-Activated Receptor-α

Figure 4

MG53 prevented cardiomyocyte injury in SIMD rats, which was reversed by GW6471. Myocardium architecture was visualized by (a) H&E staining (200x magnification, ). Myocardial injury was detected through serum levels of (b) cardiac troponin I (cTnI), (c) creatine kinase isoenzyme MB (CK-MB), (d) lactate dehydrogenase (LDH), and (e) heart-type fatty acid-binding protein (H-FABP) by the ELISA method. Data are presented as , . , , and . CLP = cecal ligation and puncture; rhMG53 = recombinant human mitsugumin-53.

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