MG53 Protects against Sepsis-Induced Myocardial Dysfunction by Upregulating Peroxisome Proliferator-Activated Receptor-α
MG53 prevented cardiomyocyte injury in SIMD rats, which was reversed by GW6471. Myocardium architecture was visualized by (a) H&E staining (200x magnification, ). Myocardial injury was detected through serum levels of (b) cardiac troponin I (cTnI), (c) creatine kinase isoenzyme MB (CK-MB), (d) lactate dehydrogenase (LDH), and (e) heart-type fatty acid-binding protein (H-FABP) by the ELISA method. Data are presented as ,.,, and . CLP = cecal ligation and puncture; rhMG53 = recombinant human mitsugumin-53.
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