Oxidative Medicine and Cellular Longevity / 2020 / Article / Fig 5

Research Article

MG53 Protects against Sepsis-Induced Myocardial Dysfunction by Upregulating Peroxisome Proliferator-Activated Receptor-α

Figure 5

MG53 attenuated myocardial oxidative stress in SIMD rats, which was abolished by GW6471. Oxidative stress injury was detected through (a) representative DHE stained images depicting in situ superoxide production (red, 400x magnification, μm), (b) quantification of DHE-signal intensity (folds of the sham group), (c) superoxide dismutase (SOD), (d) malondialdehyde (MDA), (e) glutathione (GSH) activity, and (f) free 15-F2t-isoprostane levels in the myocardium via an ELISA. Data are presented as , . , , and . CLP = cecal ligation and puncture; rhMG53 = recombinant human mitsugumin-53.

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