Sirtuin 3 Inhibits Airway Epithelial Mitochondrial Oxidative Stress in Cigarette Smoke-Induced COPD

Figure 7

Graphic summary of the protective role of Sirt3 on airway epithelial mitochondrial oxidative injury in COPD. Cigarette smoke exposure decreases Sirt3 expression in airway epithelial cells, thereby contributing to the mitochondrial damage and COPD pathogenesis through the regulation of MnSOD expression and activity. ⊥: inhibition, ↓: decline.