Red Ginseng Inhibits Tau Aggregation and Promotes Tau Dissociation In Vitro

Figure 1

The effect of Korean red ginseng extract (KRGE) on the aggregation and dissociation of tau K18. (a) The aggregation of tau K18 fragments was monitored using the thioflavin T (ThT) assay for 72 hours. (b) The fold changes of the aggregated tau were analyzed by assessing the fluorescence intensity of ThT and normalized to tau K18 monomer. (c) The fluorescence of ThT in the presence and absence of KRGE and methylene blue (MB; 100 μM). (d) The dissociation of preformed tau aggregates was analyzed by assessing the fluorescence intensity of ThT in the presence and absence of KRGE. Values represent the of the mean of three independent experiments. Statistical significance was determined by one-way analysis of variance followed by Tukey’s multiple comparison test. ; ; .

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