FoxC1-Induced Vascular Niche Improves Survival and Myocardial Repair of Mesenchymal Stem Cells in Infarcted Hearts
FoxC1-induced niche augments the effects of MSC therapy. (a) Kaplan–Meier survival rates. (b–f) Echocardiography of LVFS (b), LVEDD (c), LVEDV (d), LVAWd (e), and LVPWd (f) before MI (pre-MI), 1 d after MI (1 d post-MI), 15 d after MI (before cell therapy, 15 d post-MI), and 45 d after MI (30 d after cell therapy, 45 d post-MI). FoxC1 transfection plus MSC transplantation had higher survival rates and significant improvement in cardiac function and structural remodeling. However, this was cancelled in the siFoxC1 group. All graphical data are the .: vs. pre-MI, †vs. 1 d post-MI, ‡vs. 15 d post-MI, §vs. CON+PBS, ║vs. CON+MSCs, ¶vs. adFoxC1+PBS, #vs. adFoxC1+MSCs, and $vs. siFoxC1+PBS. Pre-MI, 1 d post-MI, and 15 d post-MI, per group. At 45 d post-MI, CON IHs: PBS, , and MSCs, ;adFoxC1 IHs: PBS, , and MSCs, ;siFoxC1 IHs: PBS, , and MSCs, ; Student’s -test.
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