Tribulus terrestris Ameliorates Oxidative Stress-Induced ARPE-19 Cell Injury through the PI3K/Akt-Nrf2 Signaling Pathway

Figure 8

EE-TT promotes the nuclear translocation of Nrf2 in H₂O₂-treated ARPE-19 cells. ARPE-19 cells were pretreated with or without 1 mM H₂O₂ for 24 h, followed by a 24 h exposure to ethanol extracts of Tribulus terrestris (EE-TT). The results of Western blot analyses for protein abundance of Nrf2 in the cytoplasm (a) and nucleus (b) with quantification data are showed and the fold changes vs. control sample (nontreatment) are presented in the bar graph. Data are shown as , , , vs. the nontreatment control sample; ^#, ^##, ^### vs. the sample with H₂O₂ treatment alone.

(a)

(b)