Gender Difference on the Effect of Omega-3 Polyunsaturated Fatty Acids on Acetaminophen-Induced Acute Liver Failure
Endogenous n-3 PUFAs exhibit sex-differential effects on APAP-induced liver damage. (a) Male or female WT and fat-1 mice () were challenged with APAP at the dose of 600 mg/kg, and the survival of mice was monitored. (b–e) APAP (400 mg/kg) was intraperitoneally injected into male or female WT and fat-1 transgenic mice (). (b, c) Serum ALT and LDH levels at different time points after APAP injection were measured. (d) Histological analysis of mouse livers was performed at 24 hours post-APAP injection by H&E staining. . (e) TUNEL staining was used to evaluate cell apoptosis in mouse livers. . , . One of the three independent experiments is shown.