| | Reference | Plant extract, dose, way and time of treatment, and animals | Inducing factor and negative effects | Protective effects of plant material | Effects of plant per se |
| | Caskurlu et al. [124] | Nigella Sativa seeds oil
Pretreatment, a single dose of 400 mg/kg p.o., 3 days before reperfusion
Male Sprague-Dawley rats, 250-300 g, 10-12 weeks | Renal reperfusion injury
45 min occlusion of the bilateral renal pedicles + reperfusion (24 h)
Kidney: tubulointerstitial damage ↑, glomerular injury score ↑, GPx, CAT ↓, MDA ↑ | Kidney: tubulointerstitial damage (++), glomerular injury score (++), GPx, CAT, MDA (++) | Not studied |
| | Sravanthi and Rao [126] | Pentapetes phoenicea methanolic extract
Pretreatment, for 10 days
100, 200 or 400 mg/kg/day
Male Wistar rats, 300–350 g | Global cerebral ischemia induced by temporary bilateral carotid artery occlusion (30 min) and subsequent 4 h reperfusion
Brain: weight, water and protein content, infarct volume and LPO ↑, SOD, CAT, GSH, GPx, GR, GST ↓ | Brain: weight, water and protein content, infarct volume, MDA, SOD, CAT, GSH, GPx, GR, GST (++ all doses)
The greater the dose the better the effect | Not studied |
| | Cakir et al. [123] | Hypericum perforatum 80% ethanol extract
50 mg/kg, i.p., at the beginning of ischemia
Male Sprague-Dawley rats, 300–350 g | Right nephrectomy and subsequent ischaemia (45 min)/reperfusion (3 h) of the left kidney
Serum: BUN and creatinine ↑
Kidney: CAT, SOD, GPx ↓, MDA ↑
Kidney: hydropic changes, tubular dilation, tubular desquamation congestion ↑ | Serum: BUN and creatinine (-)
Kidney: CAT, SOD, GPx and MDA (+++)
Kidney: tubular desquamation congestion, hydropic changes, tubular dilation (++) | Not studied |
| | Godinho et al. [125] | Trichilia catigua ethyl-acetate fraction of acetone-water (7 : 3) extract
200 mg/kg, 0.5 h before and 1 h after surgery (total dose 400 mg/kg), p.o.
Male Wistar rats, 3-month-old | Cerebral ischaemia-reperfusion 4-VO model of transient global cerebral ischaemia, 15 min ischaemia
Brain: GSH, GSH/GSSG, CAT, SOD ↓, GSSG, PCG, MDA ↑ | Brain: CAT (0), GSH, GSSG, GSH/GSSG, SOD, PCG, MDA (+++) | Not studied |
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