Differential Gender-Dependent Patterns of Cardiac Fibrosis and Fibroblast Phenotypes in Aging Mice

Figure 3

Cardiac collagen displays gender-dependent profiles with age. (a, b): Perivascular coronary, epicardial and myocardial immunofluorescence staining (594 nm) for collagen I (Col I) and collagen III (Col III) of histological sections obtained from young and aged mice of both sexes, as well as quantifications of the respective stained zones. Nuclei are stained blue with DAPI. White asterisks indicate coronary vessels. Scale bars: 50 μm. Magnifications: x200. animals per group, fields of view per condition. , and vs young male and female, , and vs aged female or male.

(a)

(b)