Ganoderic Acid D Protects Human Amniotic Mesenchymal Stem Cells against Oxidative Stress-Induced Senescence through the PERK/NRF2 Signaling Pathway
Antisenescence effect of GA-D on hAMSCs through the regulation of the PERK/NRF2 signaling pathway. (a) Changes in senescence-related genes after GA-D pretreatment. (b) Changes in n-NRF2, t-NRF2, p-PERK, PERK, and PRDX3 expression in hAMSCs treated with different treatments. (c, d) Relative expression levels of n-NRF2 and t-NRF2. (e, f) Relative expression levels of p-PERK and PERK. (g) Relative expression level of PRDX3. Normal control group (black); H2O2-induced model group (red); GA-D group (blue); GA-D plus GSK2656157 group (gray); GA-D plus ML385 group (green). GA-D: ganoderic acid D; n-NRF2: nuclear NRF2 protein; t-NRF2: total NRF2 protein; p-PERK: phosphorylated PERK protein. Data are presented as ,,,.
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