Ganoderic Acid D Protects Human Amniotic Mesenchymal Stem Cells against Oxidative Stress-Induced Senescence through the PERK/NRF2 Signaling Pathway
Antisenescence of GA-D was attenuated after inhibition of the PERK/NRF2 signaling pathway. (a, b) Intracellular ROS levels after inhibition of PERK and NRF2 expression. . (c, d) Changes of β-galactosidase expression in hAMSCs after inhibition of PERK and NRF2 expression. . Data are presented as ,,. (e) The ability of hAMSCs to differentiate into osteoblasts was analyzed by alkaline phosphatase staining. . (f) The capability of hAMSCs to differentiate into chondrocytes was detected by toluidine blue staining. GA-D: ganoderic acid D. .
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