Immunosuppressant-Induced Oxidative Stress and Iron: A Paradigm Shift from Systemic to Intrahepatic Abnormalities

Figure 8

Microphotographs of Prussian blue iron-stained splenic sections of the control (a) and tacrolimus-induced APR at 6 h (b), 12 h (c), 24 h (d), and 48 h (e) time points. Iron contents are dark blue in color. Splenic sections after the use of tacrolimus revealed remarkable fall of iron contents in the red pulp at all experimental time points in comparison to control tissues.

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