Improvement of Endothelial Dysfunction of Berberine in Atherosclerotic Mice and Mechanism Exploring through TMT-Based Proteomics

Figure 8

Schematic diagram of the mechanisms by which berberine ameliorates endothelial dysfunction and protects against atherosclerosis. In atherosclerotic mice, berberine regulated lipid metabolism, alleviated atherosclerotic lesions, attenuated oxidative stress and inflammation, and ameliorated endothelial dysfunction, thus restoring endothelium-dependent vasodilatation to protect against atherosclerosis. Regulation of mitochondrial dysfunction might be potential mechanisms underlying this protection.