NAC Supplementation of Hyperglycemic Rats Prevents the Development of Insulin Resistance and Improves Antioxidant Status but Only Alleviates General and Salivary Gland Oxidative Stress

Table 1

General characteristics of rats.

Before NAC supplementation
	C		HFD		value
Body weight (g)					<0.0001
Food intake (mg/day)					<0.0001
Glucose (mg/dL)					<0.0001
After NAC supplementation
	C	C+NAC	HFD	HFD+NAC	ANOVA
Body weight (g)			^a	^b	<0.0001
Food intake (mg/day)			^a	^b	<0.0001
Glucose (mg/dL)			^a	^b	<0.0001
Insulin (mIU/mL)			^a	^b	<0.0001
HOMA-IR			^a	^b	<0.0001

C: control group; HFD: high-fat-fed group; C+NAC: control rats+N-acetylcysteine supplementation; HFD+NAC: high-fat-fed rats+N-acetylcysteine supplementation; HOMA-IR: homeostasis model assessment of insulin resistance; ^a vs. C; ^b vs. HFD.