New 2-Acetyl-3-aminophenyl-1,4-naphthoquinones: Synthesis and In Vitro Antiproliferative Activities on Breast and Prostate Human Cancer Cells

Table 1

Synthesis of 2-acyl-3-aminophenylnaphthoquinones 16-28 from 2-acylnaphthoquinones 9-15, N, N-dimethylaniline and 2,5-dimethoxyaniline.

Acylquinone	Product	Structure	Time(hrs)	Yield(%)
10	16		3	65
11	17		5	33
12	18		240	91
13	19		216	81
14	20		28	98
15	21		72	94
9	22		48	77
10	23		1.5	63
11	24		2	63
12	25		4	91
13	26		3	87
14	27		2.5	83
15	28		2	91

Isolated by column chromatography. Yields are based on the corresponding acetylnaphthohydroquinones 2-8.