Research Article

Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice

Figure 6

Resveratrol restored synaptic protein expression ex vivo and in vitro. (a) Representative western blot bands of synapsin1, VGluT1, PSD95, and Homer1a protein in the developing mouse hippocampus between groups (control group vs. sevoflurane group) and treatments (DMSO or resveratrol). (b) Representative western blot bands of synapsin1, VGluT1, PSD95, and Homer1a protein in primary hippocampal neurons between groups (control group vs. sevoflurane group) and treatments (DMSO or resveratrol). (c, e, g, i) Densitometry quantification of synapsin1, VGluT1, PSD95, and Homer1a in vivo, respectively. (d, f, h, j) Densitometry quantification of synapsin1, VGluT1, PSD95, and Homer1a in vitro, respectively. Data are shown as ( per group). , .
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