Proanthocyanidins-Mediated Nrf2 Activation Ameliorates Glucocorticoid-Induced Oxidative Stress and Mitochondrial Dysfunction in Osteoblasts
PAC suppressed Dex-induced apoptosis in osteoblasts. (a–d) Expression levels of cleaved caspase-3, Bcl-2, and Bax in the differentially treated osteoblasts. (e) Representative fluorescence images showing coculture with PAC (1 μM) reduced Dex-induced osteoblast apoptosis. (f) Caspase-3 activity in the differentially treated osteoblasts. The data in the figures represent the of 5 times in duplicates. versus the untreated group, ## versus the Dex group.