Proanthocyanidins-Mediated Nrf2 Activation Ameliorates Glucocorticoid-Induced Oxidative Stress and Mitochondrial Dysfunction in Osteoblasts
PAC restored differentiation and mineralization of Dex-treated osteoblast. Representative images showing (a) ALP staining on the 7th day and (b) ARS staining on the 21st day of osteogenic induction in differentially treated osteoblasts. (c–f) Expression levels of RUNX2, COL1A1, and OCN in the differentially treated osteoblasts. Data are the of 3 independent experiments. versus the untreated group, ## versus the Dex group.