Proanthocyanidins-Mediated Nrf2 Activation Ameliorates Glucocorticoid-Induced Oxidative Stress and Mitochondrial Dysfunction in Osteoblasts

<div>The Nrf2 pathway mediated the osteoprotective effects of PAC. Wild type (Nrf2 con) and Nrf2-knockdown osteoblasts were treated 1 <i>μ</i>M PAC with/out 5 <i>μ</i>M Dex pretreatment for 2 days. (a–d) Immunoblot showing RUNX2, COL1A1, and OCN in the differentially treated osteoblasts. Representative images showing ALP (e) staining on the 7<sup>th</sup> day and (f) ARS staining on the 21<sup>st</sup> day of osteogenic induction in differentially treated osteoblasts. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Proanthocyanidins-Mediated Nrf2 Activation Ameliorates Glucocorticoid-Induced Oxidative Stress and Mitochondrial Dysfunction in Osteoblasts 

Figure 6 | Proanthocyanidins-Mediated Nrf2 Activation Ameliorates Glucocorticoid-Induced Oxidative Stress and Mitochondrial Dysfunction in Osteoblasts 