Proanthocyanidins-Mediated Nrf2 Activation Ameliorates Glucocorticoid-Induced Oxidative Stress and Mitochondrial Dysfunction in Osteoblasts
PAC treatment mitigated the development of GIOP in vivo. (a–e) Representative micro-CT images of the longitudinal and transverse sections of the distal femurs and the BV/TV, Tb.Sp, Tb.N, and Tb.Th values in the differentially treated animals. (f) Representative images of H&E staining, Masson’s staining, and Nrf2 immunohistochemical (IHC) staining of the metaphyseal tissue of the thigh and (h) quantification of IHC. (g, i) Representative immunofluorescence image and quantification of the Nrf2 expression. Data are expressed as of 3 times in duplicates. vs the SHAM group, ## vs. the DEX group.