Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades

Table 1

Level of sphingosine, sphingosine 1P (S-1P), and adenosine released by platelets exposed to Ticagrelor.

	Sphingosine (ng/mL)	S-1P (ng/mL)	Adenosine (ng/mL)
Control
Ticagrelor

Level of sphingosine, S-1P, and adenosine, measured with UHPLC-tandem mass analysis, in the supernatant of human platelet subjected to stirring (1200 rpm speed at 37°C) incubated in absence and presence of Ticagrelor (5000 ng/mL, 30 min). Data analyzed by Student’s t test and expressed as mean ± SEM; per group in duplicate. Statistical significance: vs. control.