ZNRD1 and Its Antisense Long Noncoding RNA ZNRD1-AS1 Are Oppositely Regulated by Cold Atmospheric Plasma in Breast Cancer Cells

<div>DNA methylation and expression profile of ZNRD1 and ZNRD1-AS1 in breast cancer. (a) The methylation level of the specific CpG (CpG ID; cg02078039) at ZNRD1 promoter in breast cancer tissues, which was hypermethylated by CAP in MCF-7, was examined using the data retrieved from the TCGA Wanderer database. No significant difference was found between the normal and cancer tissues. Expression of ZNRD1 (b) and ZNRD1-AS1 (c) was analyzed for tissues in the database GEPIA. Upregulation of ZNRD1 and downregulation of ZNRD1-AS1 were observed in breast cancer tissues. <span class="nowrap"><svg height="6.1673pt" id="M23" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -5.96091 6.6501 6.1673" width="6.6501pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z"></path></g></svg>:</span> sample number.</div>

Oxidative Medicine and Cellular Longevity

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Figure 2

Figure 2: ZNRD1 and Its Antisense Long Noncoding RNA ZNRD1-AS1 Are Oppositely Regulated by Cold Atmospheric Plasma in Breast Cancer Cells 