Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left"></td><td class="align_center">Reactive astrocytes</td><td class="align_center">Scar-forming astrocytes</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">Marker gene</td><td class="align_center">Nes, Ctnnb1, Plaur, Mmp2, Mmp13, Axin2</td><td class="align_center">Cdh2, Sox9, Xylt1, Chst11, Csgalnact1, Acan, Pcan, Slit2</td></tr><tr><td class="align_left">Function</td><td class="align_center">(1) Seclude inflammatory cells<br/>(2) Lead to tissue repair and functional improvement</td><td class="align_center">(1) Form astrocytic scar<br/>(2) Impede CNS axonal regeneration resulting in limited functional recovery</td></tr><tr><td class="align_left">Emergence time</td><td class="align_center">3 d–14 d</td><td class="align_center">14 d</td></tr><tr><td class="align_left">References</td><td class="align_center">[<a href="/journals/omcl/2020/9494352/#B10" target="_blank">10</a>]</td><td class="align_center">[<a href="/journals/omcl/2020/9494352/#B14" target="_blank">14</a>, <a href="/journals/omcl/2020/9494352/#B148" target="_blank">148</a>]</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>Mmp2: matrix metallopeptidase 2; Chst11: carbohydrate sulfotransferase 11; Csgalnact1: chondroitin sulfate N-acetylgalactosaminyltransferase 1; Acan: aggrecan; Slit2: slit guidance ligand 2.<br/></div></td></tr></table>

<div>Some specific characteristics of reactive astrocytes and scar-forming astrocytes.</div>

Oxidative Medicine and Cellular Longevity

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Table 4

Table 4: Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy 