Oxidative Medicine and Cellular Longevity / 2020 / Article / Fig 4

Research Article

Targeting the Nrf2/ARE Signalling Pathway to Mitigate Isoproterenol-Induced Cardiac Hypertrophy: Plausible Role of Hesperetin in Redox Homeostasis

Figure 4

Hesperetin mediated activation of Nrf2. (a) RT-PCR analysis of Nrf2 (left panel) and the relative mRNA levels (right). (b) Immunoblot analysis of cytosolic and nuclear Nrf2 and its regulators. (c) Bar plots showing the densitometric analysis of cytosolic and nuclear Nrf2, Keap1, Cullin3, and MafG. Actin served as a loading control. The band intensity was normalized to that of actin and Lamin B. Results are shown as the mean ± SEM of three separate experiments. Statistical significance (, , and ; ns: not significant) was calculated by Student-Newman-Keuls and Tukey post hoc tests.

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