The Effects and Mechanism of Quercetin Dietary Supplementation in Streptozotocin-Induced Hyperglycemic Arbor Acre Broilers

Table 7

The effects of quercetin dietary supplementation on mRNA expression of genes relating to the PI3K/PKB insulin signaling pathway.

Measurements	NC	HC	0.02	0.04	0.06
IR	^b	^a	^b	^b	^ab
IRS-1	^ab	^b	^a	^a	^ab
PI3K	^bc	^a	^b	^c	^ab
PKB/Akt	^b	^a	^c	^bc	^bc
GSK-3β	^ab	^a	^b	^b	^b

Genes relating to the PI3K/PKB insulin signaling pathway: IR (insulin receptor), IRS-1 (insulin receptor substrate-1), PI3K (phosphatidylinositol-3-kinase), PKB/Akt (protein kinase B), and GSK-3β (glycogen synthase kinase-3β). NC (normal control broilers), HC (STZ-induced broilers), and quercetin (0.02%, 0.04%, and 0.06%) groups. Statistical analysis was performed by one-way ANOVA followed by Tukey’s test. Values are expressed as the and . Values with different letters are significantly different ().