LCZ696 Ameliorates Oxidative Stress and Pressure Overload-Induced Pathological Cardiac Remodeling by Regulating the Sirt3/MnSOD Pathway
LCZ696 improved cardiac function in pressure overload-induced cardiac hypertrophy. (a) Representative images of echocardiography for sham or TAC mice treated with vehicle or LCZ696 for 4 weeks. (b) Cardiac function as determined by echocardiography ( mice per group). (c) Statistics analysis of HW/BW, HW/TL, and LW/TL for different groups ( mice per group). (d) Anatomical view of the whole heart in different groups under a dissecting microscope and representative images of cross-sectional HE staining. Data are presented as . vs. sham+vehicle group, # vs. TAC+vehicle group. BW: body weight; HW: heart weight; LW: lung weight; TL: tibia length; HE: hematoxylin-eosin; LVEF: left ventricular ejection fraction; LVFS: left ventricular fractional shortening; LVIDd: left ventricular end-diastolic diameter; LVIDs: left ventricular end-systolic diameter; TAC: transverse aortic constriction.