LCZ696 Ameliorates Oxidative Stress and Pressure Overload-Induced Pathological Cardiac Remodeling by Regulating the Sirt3/MnSOD Pathway

Figure 4

LCZ696 treatment mitigated TAC-induced oxidative stress. (a) Representative immunohistochemical staining images of nitrotyrosine (NT) performed to assess myocardial nitrotyrosine production in different groups. (b) Representative immunohistochemical staining images of 4 hydroxynonenal (4-HNE) performed to assess myocardial lipid peroxidation. (c) Representative immunofluorescence staining images of dihydroethidium (DHE) performed to assess myocardial ROS accumulation.

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