Research Article

Irisin Rescues Blood-Brain Barrier Permeability following Traumatic Brain Injury and Contributes to the Neuroprotection of Exercise in Traumatic Brain Injury

Figure 4

Effects of exogenous irisin on BBB integrity at 24 h after TBI in mice. (a–d) The expressions of occludin, ZO-1, and claudin-5 in brain tissue at 24 h after TBI using western blotting analysis. (e–g) Electron microscopic examination of microvasculature in the brain tissue at 24 h after TBI. Cap: capillary; TJ: tight junction; End: endothelial cell. Data are expressed as the . Scale bars: 1.0 μm. . Significance was determined by one-way ANOVA and Dunnett’s post hoc analysis. versus Sham group; # versus TBI group.
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