Research Article

Buyang Huanwu Decoction Enhances Revascularization via Akt/GSK3β/NRF2 Pathway in Diabetic Hindlimb Ischemia

Figure 6

BHD promotes revascularization of hindlimb of HLI mice via AKT/GSK3β/NRF2 signal pathway. (a) The mRNA expression of NRF2 after injection of Ad-NRF2-shRNA (). (b, c) The tissue perfusion of hindlimb in HLI mice after 0, 7, and 14 days of BHD treatment (). (d–f) The protein expression and quantitative analysis of NRF2, VEGFA, TNF-α, IL-1β, IL-6, CAT, NQO-1, and HO-1 and the phosphorylation and quantitative analysis of Akt and GSK3β in ischemic area after 14 days of BHD treatment (). . NS, ; , compared with HLI+BHD+sh-NRF2 group.