ALDH2/SIRT1 Contributes to Type 1 and Type 2 Diabetes-Induced Retinopathy through Depressing Oxidative Stress
The number of retinal cell layers in the CON, T1DM, and T2DM groups detected by HE staining after a 12-week study: (a) the representative HE staining picture; (b) the thickness of OS/IS layer; (c) the layer of ONL cells; (d) the layer of INL cells; (e) the presented TUNEL images; (f) the representative Western blotting picture of Caspase 3, Bcl-2, and Bax; (g) the relative protein expression of Caspase 3; (h) the relative protein expression of Bcl-2; (i) the relative protein expression of Bax. INL: inner nuclear layer; ONL: outer nuclear layer; IS/OS: inner and outer segment layer; RPE: retinal pigment epithelial. Scale bar: 100 μm. Values are presented as ,-6. , and : the T1DM group and the T2DM group vs. the CON group; #,##, and ###: the T2DM group vs. the T1DM group.
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