Jie-Yu-He-Huan Capsule Ameliorates Anxiety-Like Behaviours in Rats Exposed to Chronic Restraint Stress via the cAMP/PKA/CREB/BDNF Signalling Pathway

Figure 6

High-dose Jie-Yu-He-Huan capsule treatment has a therapeutic effect on altered glucocorticoid receptor (GR), 5-hydroxytryptamine 1A receptor (5-HT1AR), and monoamine oxidase A (MAO-A) expression caused by chronic restraint stress. (a) GR mRNA expression in the prefrontal cortex (PFC). (b) GR protein expression in the PFC. (c) GR mRNA expression in the hippocampus. (d) GR protein expression in the hippocampus. (e) Representative western blot protein bands of GR expression exhibiting the differences among groups. (f) 5-HT1AR mRNA expression in the PFC. (g) 5-HT1AR protein expression in the PFC. (h) 5-HT1AR mRNA expression in the hippocampus. (i) 5-HT1AR protein expression in the hippocampus. (j) Representative western blot protein bands of 5-HT1AR expression showing the differences among groups. (k) MAO-A mRNA expression in the PFC. (l) MAO-A protein expression in the PFC. (m) MAO-A mRNA expression in the hippocampus. (n) MAO-A protein expression in the hippocampus. (o) Representative western blot protein bands of MAO-A expression showing the differences among groups. compared to the control group, compared to the control group, ^# compared to the model group, ^## compared to the model group, and ^### compared to the model group ( in each group, unpaired -test). Data are expressed as the . The small circles represent individual data points.

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