Research Article

Chronic Intermittent Hypoxia Regulates CaMKII-Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm

Figure 4

CIH regulates CaMKII-dependent MAPK signaling. (a) Apoe-/- mice infused with Ang II and then exposed to CIH or normal conditions. Aortas tissues were collected for RNA sequencing and KEGG analysis. Top 30 of enriched signaling in aortas tissues were shown. (b) Hierarchical clustering and heat map showing the enrichment of the calcium signaling pathway genes in aorta tissues pretreated with normoxia or CIH. Red and blue indicate up- and downregulation, respectively. (c) qRT-PCR analysis of the mRNA expression levels of 11 calcium-related genes in aorta tissues treated with normoxia or CIH (). (d) Representative image of Western blot. (e) Quantification of CaMKII, p38, and Jnk from Western blot (). , , and .
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