Oxidative Stress Genes in Diabetes Mellitus Type 2: Association with Diabetic Kidney Disease

Table 2

The single nucleotide polymorphisms (SNPs) of the genes that attained a significant association with diabetic kidney disease in diabetic type 2 patients of Greek Caucasian origin. Polymorphisms are presented by level of significance based on increasing value. The minor allele responsible for the SNP variant, the percentage of minor allele appearance in both case and control groups, and the major allele are shown. SNP: single nucleotide polymorphism; OR: odds ratio; CI: confidence interval; SE: standard error; NC: not calculable.

Chromosome	SNP-gene	Minor allele	% of minor allele in case group patients	% of minor allele in control group patients	Major allele		value	Odds ratio (OR) (CI: confidence interval)	Standard error (SE)
4	rs7685225-SPP1	C	25.21	37.27	T	10.28	0.001	0.567 (0.4-0.81)	0.1779
2	rs6588678-TPO	A	51.24	38.86	G	9.743	0.002	1.653 (1.2-2.27)	0.1616
2	rs56307213-TTN	G	4.959	1.136	C	9.385	0.002	4.539 (1.58-13.04)	0.5385
2	rs72648987-TTN	A	4.959	1.142	G	9.318	0.002	4.518 (1.573-12.98)	0.5385
2	rs9678469-TPO	G	17.36	9.545	A	8.818	0.002	1.99 (1.256-3.153)	0.2348
2	rs72650006-TTN	A	6.25	2.074	T	7.849	0.005	3.148 (1.356-7.307)	0.4296
2	rs17532665-SGO2	G	18.6	10.91	A	7.832	0.005	1.865 (1.2-2.9)	0.2251
7	rs7830-NOS3	A	40.91	30.23	C	7.937	0.005	1.598 (1.152-2.217)	0.1669
10	rs45458497-PDLIM1	C	4.545	1.142	T	7.861	0.005	4.124 (1.416-12.01)	0.5455
2	rs17448235-SGO2	G	18.6	11.47	A	6.561	0.01	1.763 (1.138-2.732)	0.2234
8	rs11780592-CLU	G	25	17.05	A	6.176	0.013	1.622 (1.105-2.381)	0.1957
2	rs1567919-TPO	T	0	2.273	G	5.582	0.018	0	Infinite
2	rs13431646-TPO	T	0	2.273	C	5.582	0.018	0	Infinite
2	rs72677233-TTN	T	1.24	0	C	5.479	0.019	NC	NC
2	rs72646855-TTN	C	1.24	0	T	5.454	0.019	NC	NC
11	rs486584-CCS	G	43.39	52.73	A	5.447	0.019	0.6871 (0.5011-0.9422)	0.1611
19	rs201633492-GPX4	A	1.24	0	G	5.479	0.019	NC	NC
22	rs201971987-TXNRD2	G	1.24	0	A	5.479	0.019	NC	NC
22	rs737866-TXNRD2	G	38.02	29.32	A	5.393	0.02	1.479 (1.062-2.059)	0.1688
4	rs2725236-SPP1	T	38.02	46.82	C	4.916	0.026	0.6967 (0.5059-0.9595)	0.1633
2	rs6732480-TPO	T	51.24	42.5	C	4.807	0.028	1.422 (1.038-1.948)	0.1607
8	rs2741335-EPHX2	G	38.84	30.68	T	4.663	0.031	1.435 (1.033-1.993)	0.1676
11	rs3019593-MTL5	G	11.57	6.818	A	4.531	0.033	1.788 (1.041-3.071)	0.276
2	rs2048727-TPO	A	42.5	34.32	G	4.45	0.035	1.415 (1.024-1.954)	0.1647
17	rs9904720-EPX	A	37.19	29.32	C	4.438	0.035	1.427 (1.024-1.989)	0.1693
5	rs2230303-GPX3	G	1.653	0.2273	T	4.36	0.036	7.378 (0.82-66.39)	1.121
4	rs6833161-SPP1	T	33.88	42.01	C	4.321	0.037	0.7075 (0.5102-0.981)	0.1668
5	rs8177413-GPX3	C	1.653	0.2294	G	4.308	0.037	7.311 (0.8125-65.78)	1.121
8	rs7824574-CLU	A	5.785	10.45	C	4.243	0.039	0.5259 (0.2829-0.9778)	0.3164
22	rs12106549-TXNRD2	T	25.62	18.86	G	4.257	0.039	1.482 (1.019-2.155)	0.1911
17	rs14309-ALOX12	A	7.438	12.5	G	4.186	0.04	0.5625 (0.3222-0.9819)	0.2843
6	rs1293928-IPCEF1	G	30.58	38.41	A	4.174	0.041	0.7063 (0.5057-0.9866)	0.1705
6	rs6905523-GSTA7P	G	26.03	19.32	A	4.143	0.041	1.47 (1.013-2.133)	0.1898
8	rs10087808-OXR1	G	22.31	29.55	A	4.144	0.042	0.6849 (0.4753-0.9871)	0.1864
6	rs35062161-GPX6	T	3.719	1.364	A	4.027	0.044	2.794 (0.9824-7.946)	0.5333
8	rs10109171-OXR1	A	38.43	30.82	G	4.048	0.044	1.401 (1.008-1.947)	0.1678
2	rs2465661-AOX1	T	38.02	45.91	C	3.966	0.046	0.7226 (0.5246-0.9954)	0.1634
7	rs6947821-NOS3	C	29.75	37.27	T	3.902	0.048	0.7128 (0.5091-0.998)	0.1717
8	rs10108813-OXR1	C	22.73	29.77	T	3.907	0.048	0.6938 (0.4823-0.9979)	0.1855
6	rs72944451-GSTA4	T	2.479	68.18	G	3.874	0.049	3.703 (0.9179-14.94)	0.7117
8	rs1503573-OXR1	G	42.15	50	A	3.862	0.049	0.7286 (0.531-0.9996)	0.1614
17	rs11652709-EPX	C	37.6	30.23	G	3.851	0.049	1.391 (1-1.935)	0.1685
20	rs6052780-PRNP	A	1.65	4.545	G	3.848	0.049	0.3529 (0.1192-1.045)	0.5537