Pharmacological Activation of Nrf2 by Rosolic Acid Attenuates Endoplasmic Reticulum Stress in Endothelial Cells

<div>Nrf2 activation potential of Rosolic acid as assessed by ARE-Luciferase Reporter Assay. (a) HEK293T cells were transfected with either ARE-hNQO1/ARE-GST luciferase vector. Transfected cells were treated with Rosolic acid (0, 2, 5, 10, and 20 <i>μ</i>M) for 8 h. A known Nrf2 activator, RRx, was used as a reference control. Luciferase activity was measured as described in methods and expressed as fold induction relative to values obtained from control cells. Photon flux data were normalized to total protein. Effect of Rosolic acid on Nrf2 expression in EA.hy926 cells (b). 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Pharmacological Activation of Nrf2 by Rosolic Acid Attenuates Endoplasmic Reticulum Stress in Endothelial Cells 